1) Open up TF2, and go into Options. It’s at the bottom right of the current startup screen.
Keyboard: I’d leave your keyboard as is, unless you prefer to use any keys other than wsad for movement (perhaps if you’re lefthanded) and some people like to move their ‘Call Medic’ bind to a different button, but I’m perfectly fine leaving it at e.
Mouse: No mouse acceleration. Turn that off. We’ll talk about mouse sensitivity later, since it’s something highly individual, but there are some rules of thumb.
Video: I, as well as a lot of other competitive players, like to run the game in a window. Running the game in a window is easy because it lets you tab between the game, a chat client/IRC, and a talk client like Mumble or Vent easily; but it’s only really necessary if you’ll be using these things. It’s up to you to fullscreen or not, but remember that windowing a game may give you worse fps and lag your game more if you have a lower quality computer. Your computer uses more effort to render it all, you know. This is the first part of my launch options for the game: -windowed -w 1700 -h 930 This sets the size of the window I will have in window mode. The window is slightly smaller than my screen, which is 1920x1080. By the way, using a 16:9 Widescreen aspect ratio if you can will give you a definite advantage since you’ll be able to see more.
Voice: Enable it, and boost the volume to be comfortably loud enough so you can hear voice over top of the game noise. Listening is important.
Multiplayer: Use a nice crosshair that isn’t red or blue so it doesn’t mingle with the colours of your targets. Crosshair is a personal choice up to you but I find the default crosshair to be pretty useless. I use a lime green crosshair type one.